Reorganization of neuronal circuits of the central olfactory system during postprandial sleep

نویسندگان

  • Masahiro Yamaguchi
  • Hiroyuki Manabe
  • Koshi Murata
  • Kensaku Mori
چکیده

Plastic changes in neuronal circuits often occur in association with specific behavioral states. In this review, we focus on an emerging view that neuronal circuits in the olfactory system are reorganized along the wake-sleep cycle. Olfaction is crucial to sustaining the animals' life, and odor-guided behaviors have to be newly acquired or updated to successfully cope with a changing odor world. It is therefore likely that neuronal circuits in the olfactory system are highly plastic and undergo repeated reorganization in daily life. A remarkably plastic feature of the olfactory system is that newly generated neurons are continually integrated into neuronal circuits of the olfactory bulb (OB) throughout life. New neurons in the OB undergo an extensive selection process, during which many are eliminated by apoptosis for the fine tuning of neuronal circuits. The life and death decision of new neurons occurs extensively during a short time window of sleep after food consumption (postprandial sleep), a typical daily olfactory behavior. We review recent studies that explain how olfactory information is transferred between the OB and the olfactory cortex (OC) along the course of the wake-sleep cycle. Olfactory sensory input is effectively transferred from the OB to the OC during waking, while synchronized top-down inputs from the OC to the OB are promoted during the slow-wave sleep. We discuss possible neuronal circuit mechanisms for the selection of new neurons in the OB, which involves the encoding of olfactory sensory inputs and memory trace formation during waking and internally generated activities in the OC and OB during subsequent sleep. The plastic changes in the OB and OC are well coordinated along the course of olfactory behavior during wakefulness and postbehavioral rest and sleep. We therefore propose that the olfactory system provides an excellent model in which to understand behavioral state-dependent plastic mechanisms of the neuronal circuits in the brain.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Olfactory cortex generates synchronized top-down inputs to the olfactory bulb during slow-wave sleep.

The olfactory cortex is functionally isolated from the external odor world during slow-wave sleep. However, the neuronal activity pattern in the olfactory cortex and its functional roles during slow-wave sleep are not well understood. Here, we demonstrate in freely behaving rats that the anterior piriform cortex, a major area of the olfactory cortex, repeatedly generates sharp waves that are ac...

متن کامل

Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period

Granule cells (GCs) in the mouse olfactory bulb (OB) continue to be generated in adulthood, with nearly half incorporated and the remainder eliminated. Here, we show that elimination of adult-born GCs is promoted during a short time window in the postprandial period. Under restricted feeding, the number of apoptotic GCs specifically increased within a few hours after the start of feeding. This ...

متن کامل

Sharp wave - associated synchronized inputs from the piriform cortex activate olfactory tubercle 1 neurons during slow - wave sleep 2 3

Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle 1 neurons during slow-wave sleep 2 3 Kimiya Narikiyo Abstract 18 During slow-wave sleep, anterior piriform cortex neurons show highly synchronized discharges that 19 accompany olfactory cortex sharp waves (OC-SPWs). The OC-SPW-related synchronized activity of 20 anterior piriform cortex neurons travel...

متن کامل

Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle neurons during slow-wave sleep.

During slow-wave sleep, anterior piriform cortex neurons show highly synchronized discharges that accompany olfactory cortex sharp waves (OC-SPWs). The OC-SPW-related synchronized activity of anterior piriform cortex neurons travel down to the olfactory bulb and is thought to be involved in the reorganization of bulbar neuronal circuitry. However, influences of the OC-SPW-related activity on ot...

متن کامل

Critical periods in adult neurogenesis and possible clinical utilization of new neurons

CRITICAL PERIODS IN ANIMAL AGE AND IN CELLULAR AGE IN MAMMALS In mammals, sensory and motor experiences during the neonatal and infant stages of growth induce remarkable plastic changes in the structural organization and functional properties of neuronal circuits in the brain. Following this critical period, however, experience-dependent plasticity declines significantly. The term “critical per...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2013